Best Dewormers for Cats: A Vet-Backed Guide 🐱💊

When it comes to choosing the best dewormer for cats, there’s no one-size-fits-all answer—the right choice depends on:

  • The type of worms your cat has (roundworms, hookworms, tapeworms, or others).
  • Your cat’s lifestyle (indoor vs. outdoor, exposure to fleas, raw diets, hunting habits).
  • Ease of administration (spot-on, oral tablets, or liquid).

Deworming is critical for a cat’s health, preventing issues like nutrient deficiencies, weight loss, digestive problems, and serious complications in kittens. To help you pick the best dewormer, we’ve analyzed veterinary research, clinical data, and real-world user feedback to compare the top options available.


🐾 Key Takeaways: The Best Dewormers for Cats

QuestionQuick Answer ✅
What’s the best dewormer for tapeworms?Profender or Drontal (both kill tapeworms effectively).
Which is best for roundworms and hookworms?Drontal, Profender, or NexGard Combo—Drontal is OTC, while the others require prescriptions.
Which dewormer is easiest to give?Profender & NexGard Combo (topical solutions—no pills needed!).
Best dewormer for prevention?NexGard Combo (monthly topical that also prevents fleas, ticks, and heartworms).
Which is safest for sensitive cats?Profender (lowest rate of side effects, easy to apply).
How often should I deworm my cat?Outdoor cats: every 3 months; indoor cats: yearly, unless symptoms arise.
Should I get a vet test before deworming?Yes! A fecal test ensures you use the right medication for the specific worm type.

💊 What Are the Best Dewormers for Cats?

Based on effectiveness, safety, and ease of use, three products stand out:

1️⃣ Profender Topical Solution (Vet-Prescribed, Spot-On)

  • Best for: Tapeworms, roundworms, and hookworms—great for cats who hate pills.
  • 💊 Active Ingredients: Emodepside (1.98%), Praziquantel (7.94%)
  • 🔬 How It Works: Kills adult worms and some larvae; absorbs through the skin, avoiding digestive side effects.
  • 📅 Dosing: Single-dose application, no need to pill your cat.
  • ⚠️ Side Effects: Low risk—some mild irritation at the application site (under 2% of cases).

2️⃣ Drontal Broad Spectrum Dewormer (OTC, Tablet)

  • Best for: Tapeworms, roundworms, and hookworms—widely available without a prescription.
  • 💊 Active Ingredients: Praziquantel (23 mg), Pyrantel Pamoate (18.2 mg)
  • 🔬 How It Works: Paralyzes and kills worms so they pass through the stool.
  • 📅 Dosing: One-time dose, repeated after 2-3 weeks if needed (especially for roundworm larvae).
  • ⚠️ Side Effects: Higher chance of vomiting or diarrhea (3–5% of cases) due to oral ingestion.

3️⃣ NexGard Combo (Vet-Prescribed, Monthly Prevention)

  • Best for: Prevention and treatment—kills worms, fleas, ticks, and heartworms in one.
  • 💊 Active Ingredients: Esafoxolaner (1.2%), Eprinomectin (0.4%), Praziquantel (8.3%)
  • 🔬 How It Works: Eliminates worms and prevents reinfection by killing parasites before they mature.
  • 📅 Dosing: Monthly application for continuous protection.
  • ⚠️ Side Effects: Vomiting (2–3% of cases), possible skin irritation at application site.

🔬 How Do These Dewormers Compare?

FeatureProfender 🩹 (Topical)Drontal 💊 (Tablet)NexGard Combo 🔄 (Monthly Prevention)
Type of Worms KilledTapeworms, Roundworms, HookwormsTapeworms, Roundworms, HookwormsTapeworms, Roundworms, Hookworms + Lungworms
Prescription Needed?YesNo (OTC)Yes
FormTopical (Spot-on)Oral TabletTopical (Monthly)
One-Time Treatment?YesRequires a second dose for roundworm larvaePrevents future infestations
Prevents Reinfection?❌ No❌ No✅ Yes
Ease of Use✅ Easy (topical)❌ Hard (pilling required)✅ Easy (topical)
Common Side EffectsMild skin irritationVomiting, diarrheaVomiting, mild skin irritation
Best For…Single infestations, no pillsCost-conscious owners, OTC availabilityOutdoor/high-risk cats needing prevention

👉 Expert Tip: If your cat hunts rodents or has flea exposure, tapeworms are likely—Profender or Drontal work well. If you want long-term prevention, NexGard Combo is your best bet.

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🚨 What Are the Side Effects of Cat Dewormers?

Most dewormers are well-tolerated, but some cats experience mild to moderate side effects.

🔍 Side Effects Comparison of Profender, Drontal, & NexGard Combo

Side EffectProfender 🩹Drontal 💊NexGard Combo 🔄
Vomiting 🤮Rare (<1%)Common (3–5%)Moderate (2–3%)
Diarrhea 💩Very rare (<0.5%)Mild (2–4%)Rare (1–2%)
Lethargy 😴Mild (1–2%)Mild (2%)Mild (2–3%)
Skin Irritation 🔴Mild (1–2%)NoneMild (1–2%)
Neurological (Tremors, Disorientation) ⚠️Extremely rare (<0.1%)Rare (<0.1%)Rare (<0.1%)

👉 Expert Tip: Cats with sensitive stomachs may tolerate topicals (Profender, NexGard) better than oral tablets (Drontal). If your cat vomits frequently after oral medication, talk to your vet about alternatives.


🔄 How Often Should I Deworm My Cat?

📆 Deworming Frequency Based on Lifestyle

Cat TypeDeworming ScheduleRecommended Dewormer
Indoor Cats 🏡1-2 times per year (fecal check recommended)Drontal (OTC) or Profender (prescription)
Outdoor Cats / Hunters 🌳Every 3 monthsProfender or NexGard Combo
Kittens 🍼Every 2 weeks until 3 months oldPyrantel-based dewormers (e.g., Drontal)
Multi-Cat Households 🏠🐈🐈Every 3-6 months (higher reinfection risk)NexGard Combo for prevention

👉 Expert Tip: Always check a fecal sample before deworming—guessing wastes time and money!


🐾 Final Thoughts: Which Dewormer is Right for Your Cat?

  • Profender – Best for quick, one-time treatment (tapeworms, roundworms, hookworms).
  • Drontal – Best OTC option, affordable and widely available.
  • NexGard Combo – Best for outdoor cats needing prevention.

💬 Have questions about deworming? Drop them below, and our experts will guide you! 🐱💊


🗨️ Expert Answers to Your Questions


💬 Comment 1: “How do I know if my cat needs deworming?”

Recognizing the signs of worms is essential because some infestations can go unnoticed. However, specific symptoms and behaviors can indicate the presence of intestinal parasites.

🐱 Common Signs Your Cat Needs Deworming

SymptomWorm Type Likely Present 🦠What to Look For 🔍
Weight Loss ⚖️Tapeworms, RoundwormsSudden drop in weight despite a normal or increased appetite.
Bloated Belly 🎈Roundworms (especially in kittens)Swollen stomach, looks like a “potbelly.”
Vomiting 🤮Roundworms, TapewormsWorms may be seen in vomit—look for spaghetti-like shapes.
Diarrhea or Soft Stool 💩Hookworms, RoundwormsPersistent loose stool, possibly with blood.
Visible Worms in Feces 🚨Tapeworms, RoundwormsSegments resembling grains of rice (tapeworms) or long worms (roundworms).
Scooting or Licking the Rear 🍑TapewormsIrritation around the anus, excessive licking, or dragging the bottom across the floor.

👉 Expert Tip: Even if no symptoms are visible, routine deworming is recommended—especially for outdoor cats or multi-cat households where reinfection is likely.

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💬 Comment 2: “What’s the difference between prescription and OTC dewormers?”

Prescription (Rx) dewormers are typically stronger, broader-spectrum, and require vet approval for accurate diagnosis, while over-the-counter (OTC) options are readily available but may need multiple doses for full effectiveness.

💊 Prescription vs. OTC Dewormers: What’s Best for Your Cat?

FactorPrescription (Rx) 🏥Over-the-Counter (OTC) 🏪
Strength & Efficacy 💪More potent, kills multiple life stages of worms.Effective, but may require multiple treatments.
Types of Worms Treated 🦠Covers tapeworms, roundworms, hookworms, lungworms, and more.Mostly tapeworms, roundworms, and hookworms.
Ease of Purchase 🛒Requires a vet visit for diagnosis and prescription.Can be bought online, at pet stores, or pharmacies.
Speed of ActionFast-acting, often works within 24–48 hours.Can take longer to eliminate worms completely.
Prevention Available? 🛡️Some (e.g., NexGard Combo prevents reinfestation).No—OTC products are treatment-only.

👉 Expert Tip: If your cat frequents the outdoors or has repeated infestations, a prescription dewormer (Profender or NexGard Combo) is more reliable than OTC options.


💬 Comment 3: “Can I use a dog dewormer for my cat?”

No! Dog and cat dewormers are not interchangeable—using the wrong one can be dangerous or ineffective. The dosage and active ingredients differ, and some dog-specific medications can be toxic to cats.

🚨 Why Dog Dewormers Are NOT Safe for Cats

IssueWhy It’s a Problem 🚨What to Do Instead ✅
Toxic Ingredients ☠️Some dog dewormers contain ivermectin or higher doses of praziquantel, which can be toxic to cats.Use cat-specific dewormers only.
Incorrect Dosage ⚖️Dosing for dogs is based on larger body mass, leading to potential overdose in cats.Choose a product specifically labeled for cats.
Different Worm Resistance 🦠Some worms that affect dogs aren’t the same strains that infect cats.Get a fecal test from your vet to confirm the right treatment.

👉 Expert Tip: While some active ingredients overlap, never assume a dog dewormer is safe for cats. Always read labels and consult a vet before administering any medication.


💬 Comment 4: “How long does it take for dewormers to work?”

The timeframe varies by product type, the severity of infestation, and the type of worms present. However, most dewormers start working within a few hours, with full parasite elimination within days.

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⏳ How Fast Do Dewormers Work?

Dewormer TypeTime to Kill Parasites ⏳When to Expect Results 📅
Profender (Topical Rx)24–48 hoursWorms should be fully expelled within 2–3 days.
Drontal (Oral OTC)24–72 hoursStool may contain dead worms within a few days.
NexGard Combo (Topical Rx)24–48 hoursMonthly use prevents reinfection; worms clear within a few days.
Natural Remedies (Limited Evidence)VariableNo reliable data on effectiveness.

👉 Expert Tip: A follow-up dose (if required) ensures that any hatching larvae are also eliminated—ask your vet about retreatment schedules.


💬 Comment 5: “What happens if I don’t treat my cat’s worms?”

Ignoring a worm infestation can lead to serious health complications, especially in kittens or senior cats with weaker immune systems.

🚨 Consequences of Untreated Worms in Cats

Health RiskWhat Happens? 🛑Most Affected Cats 🐱
Severe Malnutrition 🍽️Worms steal essential nutrients, leading to weight loss and weakness.Kittens, seniors, underweight cats.
Anemia (Blood Loss) 🩸Hookworms feed on blood, causing pale gums and lethargy.Kittens, outdoor cats.
Intestinal Blockage 🚨Large worm infestations can cause vomiting, diarrhea, and constipation.Cats with heavy roundworm infections.
Spread to Humans 🧍‍♂️Certain worms (like roundworms) can be transmitted to humans, causing illness.Young children, immunocompromised people.

👉 Expert Tip: Regular deworming is a must! Worms don’t always show symptoms, so treating proactively is the best defense.


💬 Comment 6: “How can I prevent my cat from getting worms again?”

After treatment, preventing reinfection is key. Cats can easily pick up new parasites through fleas, prey, or contaminated environments.

🛡️ Tips to Prevent Worm Reinfection

Prevention MethodWhy It Works ✅
Monthly Flea Control 🦟Prevents flea-borne tapeworms. Use Revolution Plus, NexGard Combo, or Advantage II.
Keep Litter Boxes Clean 🚽Regular scooping reduces exposure to contaminated feces.
Deworm Indoor Cats Annually 🏠Even indoor cats can get worms from fleas, visitors, or contaminated items.
Avoid Raw Meat or Hunting 🐭Prevents infection from rodents carrying parasites.
Wash Hands & Sanitize Bedding 🧼Helps prevent roundworm eggs from spreading in the home.

👉 Expert Tip: Outdoor cats should be dewormed every 3 months, while indoor cats benefit from yearly deworming as a precaution.


💬 Comment 7: “Why does my cat still have worms after treatment?”

There are several reasons why worms may persist even after deworming. The most common issues involve incomplete treatment, reinfection, or drug-resistant parasite strains. Identifying the root cause is crucial to ensuring a full recovery.

🐛 Why Worms Might Persist After Deworming

Possible ReasonExplanation 🧐Solution ✅
Incorrect Dosage ⚖️Some dewormers require precise weight-based dosing—an underdose may not eliminate all worms.Always use the exact dosage for your cat’s weight—consult your vet for accuracy.
Reinfection from the Environment 🌍Cats can reacquire worms from fleas, soil, or other pets.Maintain strict hygiene, flea control, and regular deworming.
Worm Life Cycle Not Fully Eliminated 🔄Some dewormers only kill adult worms, leaving larvae behind.Use follow-up doses (if recommended) to target hatching eggs and immature worms.
Ineffective or Expired Medication 💊Medications lose effectiveness if expired or not stored properly.Always use vet-approved dewormers and check expiration dates.
Wrong Dewormer for the Worm TypeNot all dewormers kill every type of worm—some only target specific species.Get a fecal test to confirm which parasite is present before treatment.

👉 Expert Tip: If worms persist more than 10-14 days after deworming, consult your vet for a stool analysis and possible alternative treatment options.


💬 Comment 8: “Can indoor cats get worms, or is deworming unnecessary?”

Indoor cats can still get worms, even if they never go outside. While the risk is lower than for outdoor cats, fleas, rodents, contaminated surfaces, and even human shoes can introduce parasites into the home.

🏡 How Indoor Cats Can Get Worms

SourceHow It Happens 🧐Prevention Tips 🛡️
Fleas & Mosquitoes 🦟Fleas carry tapeworms, and mosquitoes transmit heartworms.Use monthly flea & heartworm preventatives like NexGard Combo or Revolution Plus.
Humans Bringing in Eggs 👟Roundworm and hookworm eggs stick to shoes, clothes, and hands.Clean floors & wash hands regularly, especially after handling soil or visiting other pets.
Other Pets in the Home 🏠🐶Dogs, foster kittens, or even visiting pets can carry worms.Keep all pets on a deworming schedule.
Rodents or Bugs Indoors 🐭🪳Cats that catch mice or bugs may ingest parasites.Keep homes pest-free and don’t allow hunting.
Raw Meat or Undercooked Food 🍖Some homemade/raw diets can contain worm larvae.Only feed vet-approved, parasite-free raw diets.

👉 Expert Tip: Even indoor cats should be dewormed annually, as worms don’t require outdoor exposure to spread. A simple fecal test can determine if treatment is needed.


💬 Comment 9: “Can I see dead worms in my cat’s poop after deworming?”

Yes! After a successful deworming treatment, you may notice worms being expelled in your cat’s stool. This is completely normal and a sign the medication is working.

💩 What to Expect in Your Cat’s Poop After Deworming

ObservationWhat It Means 🧐Is It Normal? ✅
Whole Worms (Roundworms, Hookworms) 🧶The medication paralyzed the worms, which are passed intact.✅ Yes, this is expected in heavy infestations.
Broken Worm Segments (Tapeworms) 🍚Tapeworms break apart into “rice-like” segments when they die.✅ Yes, this indicates the worms are being eliminated.
Mucus or Soft Stool 💦Some intestinal irritation from passing dead worms.✅ Mild cases are normal; it should resolve in 1-2 days.
No Visible WormsSome worms dissolve or are microscopic.✅ Also normal—some dewormers break worms down before passing.

👉 Expert Tip: Dispose of feces immediately, sanitize the litter box, and wash hands thoroughly to prevent reinfection or spreading eggs.


💬 Comment 10: “Are there natural dewormers that work?”

While natural remedies are popular, there is no scientific evidence that they effectively eliminate intestinal worms in cats. Veterinarians recommend FDA-approved dewormers for reliable and safe treatment.

🌿 Do Natural Dewormers Work? What Science Says

Natural RemedyClaimed Benefit 🌱Does It Work? ❌/✅Scientific Evidence 🔬
Pumpkin Seeds 🎃Said to paralyze worms with cucurbitacin.❌ No proven effect in cats.No peer-reviewed studies confirm its effectiveness.
Diatomaceous Earth 🌾Believed to “cut” worms internally.❌ Ineffective & potentially harmful.Can cause intestinal irritation or lung damage if inhaled.
Apple Cider Vinegar 🍏Claimed to create an acidic gut environment to repel worms.❌ No effect on internal parasites.The digestive system neutralizes vinegar before it affects worms.
Herbal Mixes (e.g., Wormwood, Black Walnut) 🍃Some herbs have anti-parasitic properties.⚠️ Potentially toxic to cats!Can cause liver damage, seizures, or vomiting.

👉 Expert Tip: If you prefer natural parasite prevention, focus on regular fecal testing, flea control, and maintaining a clean home rather than relying on unproven remedies.


💬 Comment 11: “Can I give my cat dewormer as a preventive measure?”

Yes! Even if your cat isn’t showing symptoms, routine deworming is recommended—especially for outdoor cats, multi-cat households, and pets exposed to fleas or rodents.

🛡️ When Should You Deworm a Cat Without Symptoms?

Cat’s Lifestyle 🏡🌳Recommended Deworming FrequencyBest Dewormer Type 💊
Indoor Cat (No Exposure to Fleas/Rodents)Once per year (fecal test first)Drontal or Profender (as needed)
Outdoor or Hunting CatEvery 3 monthsProfender or NexGard Combo
Multi-Cat Household 🏠🐱Every 6 monthsNexGard Combo for full protection
Kittens (Under 6 Months Old) 🍼Every 2 weeks until 3 months old, then monthlyPyrantel-based dewormers

👉 Expert Tip: The best prevention includes flea control, clean litter boxes, and annual stool tests to detect worms early.


💬 Comment 12: “What should I do if my cat had a bad reaction to a dewormer?”

If your cat experiences mild side effects, they usually resolve within 24–48 hours. However, severe reactions require immediate veterinary attention.

🚨 How to Handle Dewormer Side Effects

ReactionSeverity 🚨What to Do ✅
Mild Vomiting/Diarrhea 🤮LowProvide water, small meals, and monitor symptoms.
Lethargy 😴MediumEnsure rest and hydration, call vet if it persists beyond 48 hours.
Severe Vomiting, Tremors, or Collapse ⚠️HighSeek emergency vet care immediately!

👉 Expert Tip: Always monitor your cat for 24 hours after deworming, and call your vet if symptoms worsen.


💬 Comment 13: “How often should I deworm my cat if they go outside?”

Outdoor cats face a higher risk of worm infestations due to exposure to infected rodents, fleas, soil, and other animals. Because reinfection is common, deworming must be more frequent than for indoor-only cats.

🌳 Deworming Schedule for Outdoor Cats

Risk Level 🌍Recommended Deworming Frequency ⏳Best Dewormer Type 💊
Occasionally Outdoors (Supervised Walks or Balcony Access) 🚪Every 6 monthsProfender (topical) or Drontal (oral)
Regular Outdoor Access (Patio, Yard, or Free-Roaming) 🏡Every 3 monthsProfender or NexGard Combo (for prevention)
Hunters (Rodents, Birds, Insects) 🐭🐦Every 2-3 monthsNexGard Combo (for prevention), Profender for treatment
Multi-Cat Household (Indoor & Outdoor Mix) 🏠🐱Every 3-4 monthsProfender for tapeworms, Drontal for broader coverage

👉 Expert Tip: Since tapeworms are spread by fleas, outdoor cats must be on flea prevention year-round to reduce reinfection risks.


💬 Comment 14: “Can humans get worms from cats?”

Yes, certain worms are zoonotic, meaning they can infect humans. While transmission is rare with proper hygiene, handling contaminated litter boxes, soil, or pet fur increases the risk.

🛑 Worms That Can Spread from Cats to Humans

Worm Type 🦠How Humans Get Infected 🧍‍♂️Prevention Tips 🛡️
Roundworms (Toxocara cati) 🧶Ingesting microscopic eggs from contaminated soil, litter, or hands.Wash hands after handling cats, scoop litter daily.
Hookworms (Ancylostoma spp.) 🩸Larvae can penetrate human skin, causing cutaneous larva migrans (itchy rash).Wear gloves while gardening, keep floors sanitized.
Tapeworms (Dipylidium caninum) 🍚Ingesting infected fleas (accidentally swallowing one).Keep cats on flea prevention year-round.

👉 Expert Tip: Regular deworming and flea control significantly reduce the risk of transmission to humans.


💬 Comment 15: “What’s the safest dewormer for senior cats?”

Senior cats have weaker immune systems and may have underlying health conditions, making mild, well-tolerated dewormers the best option.

🐱 Best Dewormers for Senior Cats (10+ Years Old)

Dewormer 💊Why It’s Safe for Seniors ✅Common Side Effects ⚠️
Profender (Topical)Absorbs through skin, avoids digestive upset.Mild skin irritation (<2%).
Drontal (Oral Tablet)Effective against multiple worm types, single dose.Mild nausea, lethargy (2-5%).
NexGard Combo (Topical, Monthly Prevention)Protects against worms + fleas/ticks, good for high-risk seniors.Rare vomiting (2-3%).

👉 Expert Tip: Always consult your vet before deworming a senior cat, especially if they have kidney, liver, or heart conditions.


💬 Comment 16: “Why is my cat vomiting after taking a dewormer?”

Vomiting is one of the most common side effects of oral dewormers, but the severity and duration matter when determining if intervention is needed.

🤮 Causes of Vomiting After Deworming & What to Do

Possible CauseWhy It Happens 🧐What to Do ✅
Medication Taste 😝Bitter pills can cause nausea and drooling.Try crushing and mixing with food or use a pill pocket.
Stomach Irritation 🍽️Some dewormers can be harsh on the stomach.Give with food to reduce irritation.
Worm Expulsion Reaction 🦠Dying worms release toxins, causing temporary nausea.Ensure hydration, monitor stool for worms.
Overdose or Sensitivity ⚠️Some cats are more sensitive to medication.Contact your vet if vomiting lasts beyond 24 hours.

👉 Expert Tip: Topical dewormers (Profender, NexGard Combo) are a better choice for cats with a history of vomiting after oral medication.


💬 Comment 17: “Can I deworm my cat if she’s pregnant?”

Yes, but only certain dewormers are safe for pregnant or nursing cats. Some ingredients can affect fetal development, so always consult your vet first.

🐾 Safe Deworming for Pregnant & Nursing Cats

Dewormer 💊Safe for Pregnant Cats? 🤰Safe for Nursing Kittens? 🍼
Pyrantel Pamoate (Strongid, Nemex-2)✅ Yes✅ Yes
Drontal (Praziquantel + Pyrantel)✅ Yes (vet recommended)✅ Yes
Profender (Topical)❌ No❌ No
NexGard Combo❌ No❌ No

👉 Expert Tip: For pregnant and nursing cats, pyrantel-based dewormers are safest, but always confirm with a vet before treatment.


💬 Comment 18: “Do cats need to fast before taking a dewormer?”

No, cats do not need to fast before deworming. In fact, giving dewormers with food can reduce the chances of stomach upset.

🍽️ Should Dewormers Be Given With or Without Food?

Dewormer TypeWith Food? ✅/❌Why? 🧐
Oral Tablets (Drontal, Pyrantel Pamoate) 💊✅ YesReduces stomach irritation & nausea.
Liquid Dewormers 🧴✅ YesEasier to swallow when mixed with wet food.
Topical Dewormers (Profender, NexGard Combo) 🩹❌ NoAbsorbs through skin, food has no effect.

👉 Expert Tip: Hiding tablets in treats, pill pockets, or wet food makes dosing easier and more comfortable for your cat.


💬 Comment 19: “How do I clean my house after my cat has worms?”

Sanitizing your home prevents reinfection and stops the spread of worm eggs that can linger in the environment.

🧼 Home Cleaning Guide After Deworming

Area to Clean 🏡How to Sanitize 🧽How Often? ⏳
Litter Box 🚽Empty, scrub with hot water & bleach, replace litter.Daily for 2 weeks.
Carpets & Rugs 🏠Steam clean or use vacuum with HEPA filter.Weekly for 1 month.
Pet Bedding 🛏️Wash in hot water with detergent.Twice a week.
Food & Water Bowls 🍽️Wash with hot, soapy water.Daily.
Furniture & Floors 🛋️Disinfect with pet-safe cleaners.Weekly for 1 month.

👉 Expert Tip: Vacuuming and steam cleaning are crucial for removing microscopic worm eggs from carpets and upholstery.

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